USA; Postdoc: Mechanisms of Mutagenesis
A postdoctoral position is available in the Laboratory of Molecular Genetics at the National Institute of Environmental Health Sciences. The laboratory investigates the mechanisms by which organisms produce mutations, which are being pursued by genetical and biochemical approaches using the bacterium E. coli as a model system. Specifically, we are aiming to understand the factors that determine the high-fidelity of chromosomal replication by Pol III holoenzyme complex (HE). In this project we are studying: (i) mutator mutants of E. coli whose defect is associated with the polymerase accessory factors, such as newly isolated mutator mutants of the dnaX gene; (ii) The role(s) of accessory DNA polymerases in determining DNA replication fidelity; (iii) the relative contributions of leading and lagging strand DNA replication; and (iv) the role of deoxynucleoside triphosphate (dNTP) pools in mutagenesis. A second main area of research is the mechanism of mutagenesis induced by mutagenic base analogs. Of particular interest is our discovery of a novel detoxification mechanism for N-hydroxylated base analogs, which has been found to be dependent on the molybdenum cofactor.
Candidates must have a Ph.D. degree (or equivalent) with less than five years of postdoctoral experience, and have a demonstrated experience in biochemistry, molecular biology, or genetics.
For consideration, click on the button below, or send cover letter, CV including list of publications, and the names/phone numbers/E-mail addresses of three references to:
Dr. Roel M. Schaaper
Laboratory of Molecular Genetics
National Institute of Environmental Health Sciences
MD E3-01, P.O. Box 12233
Research Triangle Park, NC 27709, USA
E-mail: schaaper@niehs.nih.gov
The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina.
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